Back to Search
Start Over
Comparative Histological and Immunohistochemical Study on The Effect of Curcumin and Atorvastatin in Induced Atherosclerosis in Aorta and Cardiac Muscle of Male Rabbits
- Source :
- The Egyptian Journal of Hospital Medicine. 76:3500-3515
- Publication Year :
- 2019
- Publisher :
- Egypts Presidential Specialized Council for Education and Scientific Research, 2019.
-
Abstract
- Background: curcumin has many pharmacological effects including antioxidant, anti-inflammation, eliminating free radicals, anti-tumor, lipid regulation and anti-coagulation. Objectives: to compare the histological effects of curcumin and atorvastatin in experimental induced atherosclerosis in the rabbit’s aorta and heart. Subjects and Methodology: thoracic aorta sections were prepared and stained by Hx&E, orcein, Masson's trichrome and immuonohistochemical staning using CD34. Cardiac sections were prepared and stained by Hx&E, Masson's trichrome stain and immuonohistochemical staning using troponin T. Morphometrical study included, the thickness of both tunica intima and media of thoracic aorta , area % of the elastic fibers contents of both tunica intima and media in thorathic aorta, and the area %of the immune reaction of CD34 in thoracic aorta . Results: the atherosclerotic group showed a significant increase in the thickness of both tunicae intima& media when compared with the control group. There was a significant decrease in elastic fibers content and significant increase in the mean area % of the immune reaction of CD34 versus control. In atorvastatin treated group: there was a significant increase in comparison to control group, while there was a significant decrease in comparison to atherosclerotic group. There was significant decrease in elastic fibers content and significant increase in the mean area % of the immune reaction of CD34 in comparison to control group. In curcumin treated group: the thickness of both tunica intima and media showed a significant increase in comparison to control group. Conclusion: curcumin has potential role in treatment of atherosclerosis and myocardial infarction.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Aorta
030102 biochemistry & molecular biology
biology
business.industry
Atorvastatin
Cardiac muscle
Tunica intima
Troponin
03 medical and health sciences
030104 developmental biology
medicine.anatomical_structure
Trichrome
medicine.artery
cardiovascular system
biology.protein
Medicine
Thoracic aorta
Trichrome stain
business
medicine.drug
Subjects
Details
- ISSN :
- 20907125
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- The Egyptian Journal of Hospital Medicine
- Accession number :
- edsair.doi...........0604d94259900be8ecd99c8c97fb79b7