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Enantioselective enzymatic acylation of 1-(3′-bromophenyl)ethylamine
- Source :
- Tetrahedron: Asymmetry. 18:1330-1337
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- An efficient biocatalytic process has been developed for the resolution of 1-(3′-bromophenyl)ethylamine ( RS )- 1 by way of enantioselective lipase-mediated ( R )-selective acylation with ethyl 2-methoxyacetate to afford ( S )-amine ( S )- 1 and ( R )-2″-methoxyacetamide (( R )- 2 ) in 91–95% and 90–92% isolated yield, respectively, and both with >99% ee.
Details
- ISSN :
- 09574166
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Tetrahedron: Asymmetry
- Accession number :
- edsair.doi...........0560147752d4181af2248bd6f25d057b