Modulation of Immune Function as a Consequence of Copper Deprivation

Considerable evidence has been presented regarding the complex relationships between nutrition, metabolism, responses to inflammation,1,2 susceptibility to neoplasia, and immunocompetence.3 These relationships, coupled with the potential effects of copper bioavailability on the outcome of toxicology studies,4 led us to evaluate the effects of diet and copper deprivation on immunocompetence.