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Fibroblast growth factor receptor-1 as a potential therapeutic target in sinonasal cancer

Authors :
Patrick L. Wagner
Glen Kristiansen
Sven Perner
Robert Kirsten
Abbas Agaimy
Sebastian Huss
Maike Bode
Claudia Lengerke
Stephan Ihrler
Friederike Göke
Andreas Schröck
Alina Franzen
Friedrich Bootz
Source :
Head & Neck.
Publication Year :
2014
Publisher :
Wiley, 2014.

Abstract

Background Despite multimodal treatment, sinonasal malignancies have an unfavorable prognosis. The purpose of this study was to elucidate if these tumors harbor amplifications of the fibroblast growth factor receptor 1 (FGFR1) gene, which has recently been identified as a potential therapeutic target in squamous cell lung cancer. Methods One hundred twelve primary tumors (including squamous cell carcinoma [SCC], carcinoma associated with an inverted papilloma, sinonasal undifferentiated carcinoma [SNUC], adenocarcinoma, adenoid cystic carcinoma [ACC], esthesioneuroblastoma, and 9 corresponding lymph node metastases) were assessed by fluorescence in situ hybridization (FISH) for FGFR1 copy number status. Human papillomavirus (HPV) status was assessed by p16 immunohistochemical as a surrogate marker. Results FGFR1 amplification was found in subsets of sinonasal SCCs (20%), carcinomas associated with an inverted papilloma (33%), and SNUCs (5%). In all cases, metastatic tumor samples shared the same FGFR1 amplification status as the corresponding primary tumor tissue. None of the FGFR1-amplified tumors expressed p16. Conclusion FGFR1 amplification represents a potential molecular target in a subset of patients with sinonasal cancer. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1253–1257, 2014

Details

ISSN :
10433074
Database :
OpenAIRE
Journal :
Head & Neck
Accession number :
edsair.doi...........0524fa0927683e17b86a35c3803f07ec