Back to Search
Start Over
VALIDATION OF MICRORNA EXPRESSION PROFILE IN ORAL LICHENOID DISEASE THROUGH CYTOLOGIC SAMPLES
- Source :
- Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 129:e135-e136
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Objective To validate oral exfoliative cytology in the analysis of the microRNA expression profile in oral lichenoid disease (OLD). Study Design The expression of 13 microRNAs was analyzed in 26 cases, 16 diagnosed as OLD and 10 controls with no oral mucosal pathology. Cytologic samples from the oral mucosa obtained using an Orcellex toothbrush were analyzed using reverse transcription-quantitative polymerase chain reaction and TaqMan microRNA assays. Results The aberrant expression was validated for 2 microRNAs (miR-146 a-5 P and miR-7-1-3 P) of those previously recognized in the biopsy study. Conclusion This is the first time that oral exfoliative cytology is validated in a microRNA study in OLD. The microRNAs validated in this study are associated with both inflammatory and carcinogenic phenomena that are involved in the etiopathogenesis of this potentially malignant oral disorder.
- Subjects :
- Pathology
medicine.medical_specialty
medicine.diagnostic_test
business.industry
Disease
MicroRNA Expression Profile
Pathology and Forensic Medicine
law.invention
stomatognathic diseases
medicine.anatomical_structure
law
Cytology
microRNA
Biopsy
medicine
TaqMan
Radiology, Nuclear Medicine and imaging
Dentistry (miscellaneous)
Surgery
Oral Surgery
Oral mucosa
business
Polymerase chain reaction
Subjects
Details
- ISSN :
- 22124403
- Volume :
- 129
- Database :
- OpenAIRE
- Journal :
- Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
- Accession number :
- edsair.doi...........04efcf87c0b72609b8e853529e3f1184