New Guanidine Alkaloids from the Leaves of Verbesina Peraffinis

Two new guanidine alkaloids, 1 and 2, were isolated from the methanol extract of the leaf of Verbesina peraffinis, in addition to four known substances: galegine, the methylamide of caffeic acid, galactitol and the flavonoid 3- O-glucosyl-(1–2)-galactoside-5,7,4′ trimethoxy-kaempferol. Their structures were determined on the basis of spectroscopic methods. The antihypertensive activity of the methanolic extract was assayed in rats using a model of hypertension induced by footshock.