Utilization of dendritic framework as a multivalent ligand: a functionalized gadolinium(III) carrier with glycoside cluster periphery

A new type of designed and functionalized ligand for a lanthanide ion based on dendritic architecture was synthesized. The dendrimers, which contain four and twelve glucose moieties on the molecular surfaces, were readily synthesized with good yields in every step. The NMR and GPC analyses precisely demonstrated successful constructions of the dendritic structures, while the formations of gadolinium chelates were deduced on the basis of HPLC study.