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Cross-Linked Castor Oil-Based Hybrid Microparticles as Drug Delivery Systems
- Source :
- ACS Sustainable Chemistry & Engineering. 5:4311-4319
- Publication Year :
- 2017
- Publisher :
- American Chemical Society (ACS), 2017.
-
Abstract
- Vegetable oil-based microparticles were elaborated using environmentally friendly chemistry for pharmaceutical applications such as drug delivery systems. Castor oil (CO) was cross-linked by sol–gel chemistry to obtain a hybrid material offering original properties. CO functionalization was successfully achieved in the bulk with 3-isocyanatopropyltriethoxysilane (IPTES), then a simple and robust o/w emulsion process allowed both shaping functionalized oil into microparticles and favoring oil cross-linking. Several parameters were studied such as the stirring mode or the gelling agent for controlling microparticle characteristics. Spherical hybrid microparticles with a monodispersed size (around 300 μm) and a hybrid composition (13% w/w of mineral part) were characterized by size measurement, electronic microscopy, energy-dispersive X-ray spectroscopy, and thermal analysis. The effectiveness of the microparticles as potential drug delivery systems using ibuprofen as model molecule was demonstrated with a l...
- Subjects :
- Materials science
Renewable Energy, Sustainability and the Environment
General Chemical Engineering
Nanotechnology
02 engineering and technology
General Chemistry
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
0104 chemical sciences
Vegetable oil
Castor oil
Drug delivery
Emulsion
medicine
Environmental Chemistry
Surface modification
Microparticle
0210 nano-technology
Thermal analysis
Hybrid material
medicine.drug
Subjects
Details
- ISSN :
- 21680485
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- ACS Sustainable Chemistry & Engineering
- Accession number :
- edsair.doi...........0498cea62a118bcc0caa03166f6bc199