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The Prognostic and Predicting Roles of Tumor-Infiltrating Lymphocytes in Breast Cancer: A Meta-Analysis
- Source :
- The Open Breast Cancer Journal. 6:9-19
- Publication Year :
- 2014
- Publisher :
- Bentham Science Publishers Ltd., 2014.
-
Abstract
- Background: The relationship between lymphocyte infiltrates (LIs) and breast cancer outcome remains controversial. We performed this meta-analysis to elucidate the relationship. Methods: A literature search identified 21 eligible studies. Results: 16,097 patients were included. Multivariate analyses data for patients with unspecified receptors status showed that rich LIs expression was associated with 52% (hazard ratio (HR) = 0.48; 95% confidence interval (CI), 0.30-0.77), and 29% (HR = 0.71; 95% CI, 0.63-0.80) reduction in the risk of relapse and death, respectively. In the neoadjuvant setting, rich LIs predicted a 28% increase in complete pathological response rate. The prognostic and predictive utility of rich LIs was restricted to patients with estrogen receptor negative (ER-) or triple negative disease. Only rich CD8+ T cells tumors demonstrated clinical utility. Conclusion: LIs significantly correlated to outcome predominantly in ER- tumors. Integrating immunotherapy with conventional therapy may warrant future research in breast cancer.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Pathology
Tumor-infiltrating lymphocytes
business.industry
Lymphocyte
medicine.medical_treatment
Hazard ratio
Immunotherapy
Disease
medicine.disease
Confidence interval
medicine.anatomical_structure
Breast cancer
Meta-analysis
Internal medicine
medicine
business
Subjects
Details
- ISSN :
- 18768172
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- The Open Breast Cancer Journal
- Accession number :
- edsair.doi...........04928f43e2d57c13d032c3efcfcd34c1