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Membrane modulatory effects of omega-3 fatty acids: Analysis of molecular level interactions
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Bioactive omega-3 polyunsaturated fatty acids have been shown to reduce the risk of death in patients with cardiovascular disease and alleviate the symptoms of other inflammatory diseases. However, the mechanisms of action of these effects remain unclear. It has been postulated that omega-3 polyunsaturated fatty acids modify cell membranes by incorporation into the membrane and altering the signaling properties of cellular receptors. In this chapter, we explore the effects of omega-3 polyunsaturated fatty acids on cell membrane structure and function. We present a review of the current evidence for the health benefits of these compounds and explore the molecular mechanisms through which omega-3 polyunsaturated fatty acids interact with membrane lipids and modulate bilayer structure. Using computational models of multicomponent phospholipid bilayers, we assess the consequences of incorporation of these fatty acids on membrane lipid packing, water permeation, and membrane structure.
- Subjects :
- 0301 basic medicine
chemistry.chemical_classification
Membrane lipids
Phospholipid
030204 cardiovascular system & hematology
Eicosapentaenoic acid
Cell membrane
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
0302 clinical medicine
Membrane
medicine.anatomical_structure
chemistry
Biochemistry
Docosahexaenoic acid
Membrane fluidity
medicine
Polyunsaturated fatty acid
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........04451e0ee3e458f658cb4ae1b21181e7