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pH-Responsive Transferrin-pHlexi Particles Capable of Targeting Cells in Vitro
- Source :
- ACS Macro Letters. 6:315-320
- Publication Year :
- 2017
- Publisher :
- American Chemical Society (ACS), 2017.
-
Abstract
- Targeting nanoparticles to specific cellular receptors has the potential to deliver therapeutic compounds to target sites while minimizing side effects. To this end, we have conjugated a targeting protein, holo-transferrin (holo-Tf), to pH-responsive polymers, poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) and poly(2-(diethylamino)ethyl methacrylate)-ran-poly(2-(diisopropylamino)ethyl methacrylate (PDEAEMA-r-PDPAEMA). These protein–polymer hybrid materials were observed to self-assemble when the pH is increased above the pKa of the polymer. We demonstrate that their response to pH could be tuned depending on the polymer constituent attached to holo-Tf. Importantly, the targeting behavior of these nanoparticles could be maximized by tuning the density of holo-Tf on the nanoparticle surface by the introduction of a (PDEAEMA-r-PDPAEMA)-b-poly(ethylene glycol) (PEG) copolymer.
- Subjects :
- chemistry.chemical_classification
Materials science
Polymers and Plastics
Organic Chemistry
Radical polymerization
Nanoparticle
macromolecular substances
02 engineering and technology
Polymer
Conjugated system
010402 general chemistry
021001 nanoscience & nanotechnology
Methacrylate
01 natural sciences
3. Good health
0104 chemical sciences
Inorganic Chemistry
chemistry.chemical_compound
chemistry
PEG ratio
Polymer chemistry
Materials Chemistry
Copolymer
0210 nano-technology
Ethylene glycol
Subjects
Details
- ISSN :
- 21611653
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- ACS Macro Letters
- Accession number :
- edsair.doi...........03fc38c48908dd0f5a2489d355ce1fcd
- Full Text :
- https://doi.org/10.1021/acsmacrolett.7b00044