ChemInform Abstract: A Convenient Entry to New C-7-Modified Colchicinoids Through Azide Alkyne [3 + 2] Cycloaddition: Application of Ring-Contractive Rearrangements

Colchicine-, allocolchicine-, and N-acetylcolchinol-derived azides are prepared and employed in Cu-catalyzed Huisgen—Sharpless cycloaddition (“click”) reactions with alkynes such as (III) and (IX) under microwave irradiation, thus opening access to libraries of C-7 modified colchicinoids (triazole derivatives).