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Binary adduct formation of desipramine with dicarboxylic acids
- Source :
- Journal of Thermal Analysis and Calorimetry. 131:167-173
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- This paper presents the results obtained in a screening study for binary adduct formation of desipramine with three dicarboxylic acids—namely succinic, malonic and glutaric acids. Adduct formation is important because most tricyclic antidepressants show limited water solubility as free bases. Three binary adducts were prepared using a wet kneading method in non-homogenous media in presence of ethanol. Investigations of the solid state (ATR-FTIR, PXRD) and thermal analysis (TG/DTG/HF) were used for characterization of the prepared samples. The corroboration of data from employed instrumental techniques suggests that binary adducts in molar ratio 1:1 were obtained under the used experimental conditions.
- Subjects :
- chemistry.chemical_classification
Aqueous solution
Ethanol
Chemistry
Solid-state
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
01 natural sciences
Medicinal chemistry
0104 chemical sciences
Adduct
chemistry.chemical_compound
Desipramine
medicine
Organic chemistry
Physical and Theoretical Chemistry
0210 nano-technology
Thermal analysis
Powder diffraction
medicine.drug
Tricyclic
Subjects
Details
- ISSN :
- 15882926 and 13886150
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- Journal of Thermal Analysis and Calorimetry
- Accession number :
- edsair.doi...........03b627711ca6c69d1c5191462a7038cd