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Multiplexed molecular imaging with surface enhanced resonance Raman scattering nanoprobes reveals immunotherapy response in mice via multichannel image segmentation

Authors :
Chrysafis Andreou
Konstantinos Plakas
Naxhije Berisha
Mathieu Gigoux
Lauren E. Rosch
Rustin Mirsafavi
Anton Oseledchyk
Suchetan Pal
Dmitriy Zamarin
Taha Merghoub
Michael R. Detty
Moritz F. Kircher
Source :
Nanoscale Horizons. 7:1540-1552
Publication Year :
2022
Publisher :
Royal Society of Chemistry (RSC), 2022.

Abstract

Multiplexed imaging of 8 molecular targets with SERS nanoprobes in mice reveals spatially heterogeneous tumor responses to immunotherapy. Multichannel image segmentation enables classification of the tumor regions into responders and naïve.

Subjects

Subjects :
General Materials Science

Details

ISSN :
20556764 and 20556756
Volume :
7
Database :
OpenAIRE
Journal :
Nanoscale Horizons
Accession number :
edsair.doi...........03a3ba77ffdc861aee672dbba4d42a74
Full Text :
https://doi.org/10.1039/d2nh00331g