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Mammalian Target of Rapamycin Inhibitors in Organ Transplantation
- Source :
- Chest. 142:734-737
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- The initial enthusiasm for the advent of a potentially nonnephrotoxic immunosuppressant has been muted by data unmasking nephrotoxicity of mammalian target of rapamycin inhibitors, including renal podocyte injury resulting in proteinuria. Adverse reactions, including anemia, thrombocytopenia, hyperlipidemia, and especially diabetogenesis, have limited its use to niche indications such as prevention or amelioration of malignancy in organ transplant. The class seems to be best used to address malignancy in organ allograft recipients and as a first-line therapy in lymphangioleiomyomatosis.
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Proteinuria
business.industry
Anemia
Critical Care and Intensive Care Medicine
Malignancy
medicine.disease
Bioinformatics
Organ transplantation
Nephrotoxicity
Podocyte
medicine.anatomical_structure
Immunology
Lymphangioleiomyomatosis
Hyperlipidemia
medicine
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 00123692
- Volume :
- 142
- Database :
- OpenAIRE
- Journal :
- Chest
- Accession number :
- edsair.doi...........0393a28f71bbdc6be03b33babd84dae9