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Supramolecular Assemblies of Three New Metronidazole Derivatives Constructed with Various Dihydroxy-benzoic Acids via Hydrogen Bonds
- Source :
- Chemical Research in Chinese Universities. 36:1196-1202
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Metronidazole(MTZ) is an important antibiotic, which has been widely applied to cure protozoal and bacterial diseases for human beings or animals. Herein, three novel drug supramolecular crystals constructed by MTZ with 2,5-dihydroxy-benzoic acid(2,5-DHBA)(1), 2,6-dihydroxy-benzoic acid(2,6-DHBA)(2) and 3,5-dihydroxy-benzoic acid(3,5-DHBA)(3), respectively, have been discovered. The hydrogen bonds of N—H⋯O(O—H⋯N), C—H⋯O and O—H⋯O play important roles in the 3D supramolecular framework formation for crystals 1–3. Interestingly, due to the vary locations of the substituent groups, the two-dimensional layers in crystals 1 or 2 are constructed via intermolecular hydrogen bonds between MTZ and 2,5-DHBA or 2,6-DHBA, while in crystal 3 water molecules play a significant role except the intermolecular hydrogen bonds between MTZ and 3,5 -DHBA. In addition, five synthons of I R22(8), II R33(9) in crystal 1, III R21(4), IV R22(8) in crystal 2 and V R22(7) in crystal 3 formed through various hydrogen bonds are founded in this work. Systematic studies of syntheses, crystal structures and thermal analysis are reported.
- Subjects :
- Chemistry
Hydrogen bond
Synthon
Intermolecular force
Supramolecular chemistry
Substituent
02 engineering and technology
General Chemistry
Crystal structure
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
0104 chemical sciences
Crystal
chemistry.chemical_compound
Polymer chemistry
Molecule
0210 nano-technology
Subjects
Details
- ISSN :
- 22103171 and 10059040
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Chemical Research in Chinese Universities
- Accession number :
- edsair.doi...........038e9d119caa77d4752a85aeafa99dc3