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Metabonomic Method to Analyze the Changes in Pancreatic metabolites in Tree Shrew Traumatic Systemic Inflammatory Response Syndrome After Treatment with Umbilical Cord Mesenchymal Stem Cells

Authors :
Guang-Ping Ruan
Xiang Yao
Kai Wang
Shu-Qian Lin
Rong-Qing Pang
Xing-Hua Pan
Source :
Indian Journal of Animal Research.
Publication Year :
2023
Publisher :
Agricultural Research Communication Center, 2023.

Abstract

Background: The impact method was used to make unilateral femoral comminuted fractures in tree shrews, which were then intravenously injected with lipopolysaccharide to create a traumatic systemic inflammatory response syndrome model. Methods: The treatment group was infused with tree shrew umbilical cord mesenchymal stem cells via the tail vein. After 10 days of treatment, 6 tree shrews were killed in the control, model and treatment groups and pancreatic tissue was collected for metabonomic analysis. Result: The 25 differential metabolites in the normal, model and stem cell treatment groups showed a trend of first decreasing and then increasing and 11 metabolites showed a trend of first increasing and then decreasing. These findings are in line with the recovery of the curative effect of the stem cell therapy model group.

Details

ISSN :
09760555 and 03676722
Database :
OpenAIRE
Journal :
Indian Journal of Animal Research
Accession number :
edsair.doi...........037b06d667f64fa389333654c19694ec