Granule-mediated death by cytotoxic lymphocytes does not require mitochondrial polarization toward the immunologic synapse in target cells

To the editor: A recent article in Blood [1][1] reported that mitochondrial polarization to the immunologic synapse (IS) was required for cytotoxic lymphocyte (CL)–induced death of cells that overexpress Bcl-2. This potentially represented a significant advance in understanding CL-induced death