Subcutaneous Versus Transvenous Implantable Defibrillator in Patients with Hypertrophic Cardiomyopathy

Background: Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiomyopathy. Implantable Cardioverter Defibrillator (ICD) is important for prevention of sudden cardiac death (SCD) in patients at high risk. In recent years the subcutaneous ICD (S-ICD) has emerged as a viable alternative to the transvenous ICD (TV-ICD). The S-ICD does not require intravascular access, but cannot provide antitachycardia pacing therapy (ATP). Objective: To assess the real world incidence of ICD therapy in patients with HCM implanted with TV-ICD versus S-ICD.Methods: We compared the incidence of ATP and shock therapies between all HCM patients with S-ICD and TV-ICD enrolled in the Boston Scientific ALTITUDE database. Cumulative Kaplan Meier incidence was used to compare therapy free survival and Cox proportional hazard ratios were calculated. We performed an unmatched as well as propensity match analysis. Results: We included 2462 patients with TV-ICD and 716 patients with S-ICD followed for an average of 1348 {plus minus} 989 days. Patients with HCM and TV-ICD had significantly higher rate of device therapy as compared to those with S-ICD (31.1 vs. 14.7 therapies /100 patient year; p