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ChemInform Abstract: Optimization of a Novel Series of Selective CNS Penetrant CB2 Agonists

Authors :
Christine Watson
et al. et al.
Source :
ChemInform. 42
Publication Year :
2011
Publisher :
Wiley, 2011.

Abstract

The compound (Ia) shows excellent selectivity as CB2 agonist (EC50 2.7 nM) over the CB1 receptor and demonstrates a good central nervous system (CNS) penetration in rat.

Subjects

Subjects :
Cannabinoid receptor
medicine.anatomical_structure
Chemistry
Central nervous system
medicine
Biophysics
lipids (amino acids, peptides, and proteins)
General Medicine
Penetration (firestop)
Selectivity
Cb2 agonist

Details

ISSN :
09317597
Volume :
42
Database :
OpenAIRE
Journal :
ChemInform
Accession number :
edsair.doi...........0352bf507fba5e4fa245dc77c25652d2
Full Text :
https://doi.org/10.1002/chin.201148208
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