1308 DEVELOPMENT OF THE HIPPOCAMPAL FORMATION IN TRISOMY 16 MICE

Studies of the neuroanatomic features of murine trisomy 16 (Ts16), an animal model for human trisomy 21 (Ts 21, Down Syndrome), have focussed upon the structural and ultrastructural characteristics of germinative cells within the hippocampal formation. We prepared 5 micron plastic section serial reconstructions of the hippocampal formation of Ts16 and normal littermates from days 12 through 18 gestation.