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New series of 4(3H)-quinazolinone derivatives: syntheses and evaluation of antitumor and antiviral activities
- Source :
- Medicinal Chemistry Research. 27:571-582
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- New series of 3-(3-trifluoromethylphenyl)-6-iodo-4(3H)-quinazolinone derivatives bearing thiosemicarbazones, pyrazoles, azomethine moieties at C-2 were synthesized. The obtained products were screened for their expected anticancer activity against; human liver cancer cell line (HepG2), breast cancer cell line (MCF-7) and human lung adenocarcinoma epithelial cell line (A549) tumor cell lines. Cytotoxicity of the synthesized compounds showed good IC50 for some products in comparison with the standard drug, doxorubicin. On the other hand, antiviral activity of the synthesized products against H5N1 showed moderate to weak activity compared to Zanamivir reference drug.
- Subjects :
- Drug
010405 organic chemistry
Chemistry
media_common.quotation_subject
Organic Chemistry
010402 general chemistry
medicine.disease
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
chemistry.chemical_compound
Zanamivir
Cell culture
medicine
Adenocarcinoma
Doxorubicin
General Pharmacology, Toxicology and Pharmaceutics
Cytotoxicity
IC50
Quinazolinone
medicine.drug
media_common
Subjects
Details
- ISSN :
- 15548120 and 10542523
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Medicinal Chemistry Research
- Accession number :
- edsair.doi...........03334ef65700fd5c5be5065ca28cb877