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mTOR Inhibition Promotes Pneumonitis through Inducing Endothelial Contraction and Hyperpermeability

Authors :
Dai-Min Zhang
Chengxiu Hu
You-Qiang Su
Xiaolin Chen
Yiying Wang
QianLu Yang
Anthony G. Passerini
Qiannan Li
Xing Fan
Chongxiu Sun
Source :
American Journal of Respiratory Cell and Molecular Biology. 65:646-657
Publication Year :
2021
Publisher :
American Thoracic Society, 2021.

Abstract

Compromised endothelial (EC) barrier function is a hallmark of inflammatory diseases. Mammalian target of rapamycin (mTOR) inhibitors, widely applied as clinical therapies, cause pneumonitis throug...

Details

ISSN :
15354989 and 10441549
Volume :
65
Database :
OpenAIRE
Journal :
American Journal of Respiratory Cell and Molecular Biology
Accession number :
edsair.doi...........031908b3c1095f5f1f736da324464bf1