Image-Guided High-Dose Rate Brachytherapy in the Treatment of Liver Cancer

High-dose rate brachytherapy for primary and secondary liver malignancies is an innovative radio-oncological modality enjoying rapid acceptance and adoption in the field of interventional oncology. It is a safe and effective treatment most useful in the salvage situation in patients with large hepatic tumors or an intermediate number of lesions unsuitable for thermal ablation or stereotactic external radiotherapy. In this chapter the radiobiological and technical aspects of CT-guided brachytherapy for the treatment of liver cancers are discussed. Clinical toxicity and efficacy outcomes after this technique are described including a comprehensive data review.