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ChemInform Abstract: Catalytic Asymmetric Synthesis of Enantioenriched β-Nitronitrile Bearing a C-CF3Stereogenic Center
- Source :
- ChemInform. 47
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- CF3 substituted β-nitronitriles with an all-carbon quaternary stereogenic center have been synthesized via asymmetric cyanation reaction. In situ generated chiral TiIV salen complexes were used as catalysts for asymmetric addition of TMSCN to nitroolefins containing a trifluoromethylated prochiral center in the β-position, to afford the corresponding β-nitronitriles in excellent yield (up to 93%) with good enantioselectivity (up to 99%). This newly developed catalytic protocol led to the efficient synthesis of useful but challenging chiral α,α′-disubstituted β-amino acids.
Details
- ISSN :
- 09317597
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........025a42e4e8d514d6641b08d77c99fdf1