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In vivo anti-inflammatory and hepatoprotective activities of Orobanche crenata (Forssk.) aerial parts in relation to its phytomolecules
- Source :
- Natural Product Research. 36:1067-1072
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- A total methanolic extract and its sub-extracts of Orobanche crenata (Forssk.) aerial parts were subjected to acute toxicity, anti-inflammatory, and hepatoprotective investigations. The methanolic extract was safe upto 3 g/kg on mice. The EtOAc fraction reduced the carrageenan-induced rat paw edema better than indomethacin. It also demonstrated a drop in the elevated ALT, AST, and TB at 300 mg/kg, better than silymarin. Histopathological examination of liver cells of rats given the EtOAc fraction showed a complete absence of the CCl4-induced cloudy swelling. A phytochemical investigation of the n-hexane and EtOAc fractions yielded 11 compounds [indole-3-carboxylic acid (1), n-butyl palmitate (2), tyrosol (3), L-rhamnonic acid-1,4-lactone (4), β-sitosterol/stigmasterol mixture (5/5'), β-sitosterol/stigmasterol glycosides mixture (6/6'), chrysoeriol (7), luteolin (8), apigenin (9), crenatoside (10), and verbascoside (11)] as identified by UV, 1D & 2D NMR and ESIMS techniques. Their reported biological actions were in relation to and supported our herein detected pharmacological findings.
- Subjects :
- Stigmasterol
biology
Traditional medicine
010405 organic chemistry
Chemistry
Organic Chemistry
Plant Science
Orobanche crenata
biology.organism_classification
Chrysoeriol
01 natural sciences
Biochemistry
0104 chemical sciences
Analytical Chemistry
Tyrosol
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
Verbascoside
Phytochemical
Apigenin
Luteolin
Subjects
Details
- ISSN :
- 14786427 and 14786419
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Natural Product Research
- Accession number :
- edsair.doi...........01f947adfbea9399c283cf51335e05d6