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Total synthesis of polyamine amide spider toxin argiotoxin-636 by a practical reductive alkylation strategy
- Source :
- Tetrahedron Letters. 36:9393-9396
- Publication Year :
- 1995
- Publisher :
- Elsevier BV, 1995.
-
Abstract
- Reductive alkylation is a practical strategy for a total synthesis of spider toxin argiotoxin 636, a polyamine amide which is a selective glutamate receptor antagonist and may have potential as a neuroprotective agent. Central to this synthesis are a Swern oxidation and a reductive alkylation.
Details
- ISSN :
- 00404039
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........019d469b54264bb3145c66db5ae026ce