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Measurement of Oxygen-Derived Free Radical Generation in the Regionally-Ischemic Rat Heart by the Chemiluminescence Method
- Source :
- Japanese Journal of Pharmacology. 61:277-281
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- Effects of aniracetam on whole-cell calcium currents were studied in acutely isolated neuronal cells from postnatal rat ventromedial hypothalamus. There were three types of inward calcium currents, one low-threshold transient current and two high-threshold sustained currents. The nicardipine sensitive L-type current was activated at -20 mV or more depolarized potentials, and the omega-conotoxin sensitive N-type current was recorded at more positive potentials than the L-type. Aniracetam inhibited the N-type current in a dose-dependent manner without affecting the other two types of calcium currents. The effect appeared soon after the addition and lasted for several minutes during washing. Since the N-type current is thought to regulate the release of transmitters, the inhibitory effect may contribute to the nootropic property of aniracetam by modifying the neurotransmission.
Details
- ISSN :
- 00215198
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Japanese Journal of Pharmacology
- Accession number :
- edsair.doi...........0135cb42109390f600491b82c53f01e7