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Inhibition of matrix metalloproteinases by P1 substituted N-carboxyalkyl dipeptides
- Source :
- Bioorganic & Medicinal Chemistry Letters. 6:329-332
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Aroyl and arylacyl aminoalkyl substitutents at the P 1 position of N -carboxyalkyl dipeptides were found to enhance potency and selectivity for stromelysin-1 (MMP-3). In particular, the phthalimidobutyl and phenylpropanoylaminopropyl groups offered inhibitors of MMP-3 with K i 's of ∼ 10nM.
Details
- ISSN :
- 0960894X
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi...........00c47b295c17fc7d6039dc2b0ae11792
- Full Text :
- https://doi.org/10.1016/0960-894x(96)00024-8