Clinical effect of Mongolian medicine Qinggan Jiuwei powder in treatment of alcoholic liver fibrosis

ObjectiveTo observe the clinical effect of Mongolian medicine Qinggan Jiuwei powder in the treatment of alcoholic liver fibrosis by observing the improvement in imaging indices. MethodsA total of 104 patients with alcoholic liver fibrosis who visited Department of Gastroenterology in Horqin District First People′s Hospital in Tongliao from October 2015 to January 2017 were enrolled and randomly divided into experimental group and control group, with 52 patients in each group. The patients in the experimental group were given Mongolian medicine Qinggan Jiuwei powder, while those in the control group were given reduced glutathione tablets. Liver function parameters, liver-spleen ultrasound findings, and liver stiffness measurement (LSM) determined by FibroScan were observed before and after treatment. The independent samples t-test was used for comparison of normally distributed continuous data between groups, and the paired samples t-test was used for comparison within each group; the Wilcoxon rank sum test was used for comparison of non-normally distributed continuous data between groups. ResultsBoth groups had varying degrees of improvements in clinical symptoms and signs. Both groups had significant changes in alanine aminotransferase, aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and LSM after treatment (experimental group: Z=-3.09, -7.19, and -8.27, t=7.13, P=0.002, ＜0.001, ＜0.001, and ＜0.001; control group: Z=-3.28, -4.60, and -5.06, t=8.54. P=0.001, ＜0.001, ＜0.001, and ＜0.001). There were significant differences in AST and GGT after treatment between the two groups (Z=-2.02 and -2.15, P=0.04 and 0.03). Both groups had significant changes in oblique diameter of the right liver lobe, diameter of the portal vein, blood flow rate of the portal vein, spleen thickness, and diameter of the splenic vein after treatment (experimental group: t=6.48，11.02,2.20，3.30 and 5.30, P＜0.001, ＜0.001, =0.030, ＜0.001, and ＜0.001; control group: t=3.51、6 31、2.68、3.06、4.71, P=0.01, ＜0.001, =0.01, ＜0.001, and ＜0.001). There were significant differences in oblique diameter of the right liver lobe and diameter of the portal vein after treatment between the two groups (t=3.96 and 3.53, P=0.02 and 0.01). ConclusionMongolian medicine Qinggan Jiuwei powder has a good clinical effect in the treatment of alcoholic liver fibrosis and can effectively reduce the imaging index LSM and values measured by abdominal color Doppler ultrasound in patients with alcoholic liver fibrosis.