Pregnancy Success Prediction Using Uterine and SubEndometrial Arteries Doppler Indices Comparison Between the Trigger Day and the Mid Luteal Phase Day When Using Oral Ovarian Induction Medication in Sub Fertile Patients

Background: Doppler of uterine and sub-endometrial arteries might be beneficial for the prediction of pregnancy success. None or few studies evaluated them when using oral ovulation induction. Methods: This study is a randomized prospective study. We recruited infertile couples with PCOS or unexplained subfertility from the infertility unit at Al-Moosa Specialist Hospital in eastern province in the Kingdom of Saudi Arabia. We randomize cycles to use clomiphene or letrozole. We study the uterine arteries doppler indices difference between the hCG trigger day and the mid-luteal phase day with positive and negative pregnancy test groups. Results: In the negative pregnancy test group, there was no sufficient evidence suggesting a difference for sub endometrial artery PI and RI between the trigger day and mid-luteal phase day with a p-value of 0.95 and 0.765, respectively. For the uterine artery PI and RI, there was evidence suggesting a difference between the trigger day and the mid-luteal phase day with a p-value of .003 for both of them. In the positive pregnancy test group, there was evidence to suggest a difference between the trigger day and the mid-luteal phase day for the sub endometrial artery RI with a p-value of 0.035. However, there was no sufficient evidence to suggest that there was a difference for PI of the sub endometrial artery and the uterine artery PI and RI between the day of the trigger and mid-luteal phase day with a p-value of 0.137, 0.533 and 0.687 respectively. Conclusions: When uterine artery PI and RI decrease, we can predict failed ovulation treatment. In comparison, we can predict a successful pregnancy with increasing sub-endometrial artery RI.