Influence of vascular endothelial function and inflammatory cytokines on patients with transumbilical single-port access laparoscopic cholecystectomy

Objective: To explore the influence of vascular endothelial function and inflammatory cytokines on patients with transumbilical single-port access laparoscopic cholecystectomy (TSPALC). Methods: A total of 86 cases with laparoscopic cholecystectomy, they were divided into single span treatment group (n=46) and normal group (n=40) according to the treatment. Patients in single span treatment group were treated with TSPALC, while patients in normal group were treated with normal LC. Surgery and postoperative recovery, tested and compared vascular endothelial function index: nitric oxide (NO), endothelin (ET) and inflammation factors: interleukin-6 (IL-6) and interleukin-8 (IL-8), high sensitivity C-reactive protein (hs-CRP) before and after surgery at different time points were compared. Results: VAS score at 6 h after surgery was similar between the two groups, while the VAS score at 12 h, 24 h after surgery in two groups were significantly reduce than 6h after surgery, and the VAS score at same point in single span treatment group were significantly lower than normal group, the difference had statistical significance (P0.05). Conclusions: The vascular endothelial function injury and inflammation stress are similar between normal LC and TSPALC, but TSPALC has small trauma. The postoperative pain is light, it’s worth clinical promotion positively.