Genetic polymorphisms of CYP1A1 and risk of leukemia: a meta-analysis

Jun Lu,1,* Qian Zhao,1,2,* Ya-Jing Zhai,3 Hai-Rong He,1 Li-Hong Yang,1 Fan Gao,1 Rong-Sheng Zhou,4 Jie Zheng,1 Xian-Cang Ma1,51Clinical Research Center, The First Affiliated Hospital, Xi’an Jiaotong University, 2College of Pharmacy, Xi’an Medical University, 3Department of Pharmacy, The First Affiliated Hospital, Xi’an Jiaotong University, 4Department of Anesthesiology, The First Affiliated Hospital, Xi’an Jiaotong University, 5Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China*These authors contributed equally tothis workAbstract: The associations between CYP1A1 polymorphisms and risk of leukemia have been studied extensively, but the results have been inconsistent. Therefore, in this study, we performed a meta-analysis to clarify associations of three CYP1A1 polymorphisms (T3801C, A2455G, and C4887A) with the risks of acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML). Medline, EMBASE, and China National Knowledge Infrastructure databases were searched to collect relevant studies published up to April 20, 2015. The extracted data were analyzed statistically, and pooled odds ratios with 95% confidence intervals were calculated to quantify the associations. Overall, 26 publications were included. Finally, T3801C was associated with an increased risk of AML in Asians under the dominant model. For A2455G, the risk of ALL was increased among Caucasians in the recessive model and the allele-contrast model; A2455G was also associated with an increased risk of CML among Caucasians under the recessive model, dominant model, and allele-contrast model. For C4887A, few of the included studies produced data. In conclusion, the results suggest that Asians carrying the T3801C C allele might have an increased risk of AML and that Caucasians with the A2455G GG genotype might have an increased risk of ALL. Further investigations are needed to confirm these associations.Keywords: CYP1A1, ALL, AML, CML, polymorphism