Effects of total thoracic esophageal cancer radical surgery on postoperative pulmonary function and inflammatory factors in patients with esophageal cancer

Objective: To observe the effect of total thoracic esophageal cancer radical surgery on postoperative pulmonary function and inflammatory factors in patients with esophageal cancer. Methods: A total of 92 cases esophageal cancer patients who admitted in the hospital were randomly divided into the observation group and the control group, with 46 cases in each group. The observation group was treated with total thoracic esophageal cancer radical surgery, and the control group was treated with traditional radical resection, the lung function and the inflammatory factors levels were compared between the two groups before and after treatment. Results: Compared with the preoperative, the postoperative FEV1, FVC and FEV1/FVC in the observation group decreased slightly, but the differences were not significant, while the postoperative FEV1, FVC and FEV1/FVC in the control group were significantly decreased; the postoperative FEV1, FVC and FEV1/FVC in the observation group was (2.42±0.71) L, (3.35±0.21) L and (66.53±9.81)% respectively, all were significantly higher than that in the control group after operation. Compared with the preoperative, both two groups’ postoperative IL-6, TNF-α and hs-CRP were significantly elevated, and the differences were statistically significant; the postoperative IL-6, TNF-α and hs-CRP in the observation group was (227.53±40.13) pg/mL, (30.58±6.12) pg/mL and (25.38±5.12) mg/L respectively, all were significantly lower than that in the control group after operation. Conclusion: For patients with esophageal cancer, both two type surgery, the traditional radical resection and the total thoracic radical surgery can improve the clinical symptoms of the patients to some extent. But total thoracic surgery can lower the effects on lung function, reduce the incidence of postoperative inflammation, and worth to be further used clinically.