Relationship of the polymorphism of rs10795668 single nucleotide and the susceptibility of colorectal cancer in north China Han population

Objective To evaluate the relationship between the rs10795668 single nucleotide polymorphism (SNP) and the colorectal cancer (CRC) in north China Han population. Methods The genotype of rs10795668 SNP was detected by PCRRFLP analysis in 113 colon cancer patients, 69 rectal cancer patients, and 192 age and sex matched controls. Unconditional logistic regression were used to comparatively analyze the genotype between patients and the controls adjusted by age and sex. Results No significant difference of rs10795668 SNP was detected between colorectal cancer patients and normal controls, but it was found that an existence of interaction of gene and sex in colorectal cancer, and women with AA+AG genotype may have lower risk of colon cancer (OR3.05, 95% CI 1.47-6.35; P=0.00078). Conclusion The AA+AG genotype of rs10795668 SNP is associated with the genetic susceptibility of colon cancer, but not of rectal cancer, in north China Han women. DOI: 10.11855/j.issn.0577-7402.2015.10.10