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Increased plasma levels of tumor necrosis factor-a in asymptomatic/'indeterminate' and Chagas disease cardiomyopathy patients
- Source :
- Memórias do Instituto Oswaldo Cruz., Vol 98, Iss 3, Pp 407-412 (2003)
- Publication Year :
- 2003
- Publisher :
- Instituto Oswaldo Cruz, Ministério da Saúde, 2003.
-
Abstract
- We compared plasma tumor necrosis factor-alpha (TNF-alpha) levels among asymptomatic/"indeterminate" Chagas disease patients (ASY) and patients across the clinical spectrum of chronic Chagas disease cardiomyopathy (CCC). Idiopathic dilated cardiomyopathy (DCM) patients and normal controls (NC) were included as controls. ASY Chagas disease patients had significantly higher plasma TNF-alpha levels than NC. TNF-alpha levels among severe CCC patients with significant left ventricular (LV) dysfunction were similar to those of DCM patients, showing average 2-fold higher levels than CCC patients without LV dysfunction and ASY patients, and 8-fold higher levels than NC. In Chagas disease, chronic TNF-a production prior to heart failure may play a role in CCC progression.
Details
- Language :
- English
- ISSN :
- 16788060 and 00740276
- Volume :
- 98
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Memórias do Instituto Oswaldo Cruz.
- Accession number :
- edsair.doajarticles..7cceb60f5ecc47c2fffa28b10919cbde