Thrombocyte counts in mice after the administration of methanolic extract of Melastoma malabathricum

Objective: To investigate the effect of methanolic extract of Melastoma malabathricum (M. malabathricum) in thrombocyte counts in mice. Methods: Methanolic extract of M. malabathricum corresponding to 1.5 to 2 mg/10 g body weight in saline was administered to mices via oral route. Control group was given normal saline. Twenty five microlitres of blood were drawn at 0 h and thereafter at 1, 2, 4, 8, 12, 20 h after dosing via tail bleeding technique. The thrombocytes were counted in the triple laminated middle 25 squares of the haemocytometer using light microscope. Results: The control group showed a moderate rise after the administration of saline whereas the M. malabathricum treated group shows significant rise within 2nd h in thrombocyte counts with an increment of 51.64% compared to baseline count. Conclusions: Based on the results, it can be concluded that M. malabathricum could be a potential remedy in treating thrombocytopenic condition.