Back to Search Start Over

Study on Hemorheological Properties of Erythrocytes in Asymptomatic Hyperuricemia Rat Model

Authors :
Kuihua Li
Xiaobo Tong
Weijuan Yao
Xifu Wang
Atsushi Suzuki
Nobuo Suzuki
Source :
International Journal of Medical Research and Health Sciences, Vol 6, Iss 10, Pp 1-7 (2017)
Publication Year :
2017
Publisher :
Sumathi Publications, 2017.

Abstract

Background: Hyperuricemia causes gout syndrome, which can manifest as hemorheological damage. However, hemorheological properties have not been well characterized in asymptomatic conditions. Aims: The present study was aimed to investigate the hemorheological changes in rats with asymptomatic hyperuricemia. Methods and Materials: The rat model was established by intraperitoneal injection of 250 mg/(kg·d) oxonate acid for 8 weeks. In one group of rats, 70 mg/(kg·d) allopurinol was also administrated for the latter 4 weeks. Control rats were administered CMCNa solution and water. Results: Hyperuricemic rats had higher blood viscosity than control rats did. Moreover, their erythrocytes had reduced deformation index, orientation index, surface charges, and osmotic fragility. Treatment with allopurinol decreased the blood uric acid amounts and improved the hemorheological parameters. Conclusions: Our study suggests that there is deterioration in the hemorheology of hyperuricemic rats and that allopurinol can play a protective role on the deterioration. Therefore, hemorheology can be used as a diagnostic tool in asymptomatic hyperuricemia.

Details

Language :
English
ISSN :
23195886
Volume :
6
Issue :
10
Database :
OpenAIRE
Journal :
International Journal of Medical Research and Health Sciences
Accession number :
edsair.doajarticles..6d382031597b4d7943d9f028241a723b