Anti-inflammatory and antioxidant functions of high-density lipoprotein subclasses in patients with acute coronary syndrome

Objective To assess the anti-inflammatory and antioxidant functions of high-density lipoprotein (HDL) subclasses (HDL2 and HDL3) in patients with acute coronary syndrome (ACS), and to elucidate whether incapacitation of HDL subclasses occurred in ACS patients. Methods Forty ACS patients hospitalized in Nanfang Hospital from Jan. 2011 to Jan. 2012 (ACS group), and 40 subjects simultaneously receiving health examination (control group) were enrolled in present study. Plasma lipid and hypersensitive C reactive protein (hs-CRP) levels, HDL subclasses inflammatory index (HII), paraoxonase-1 (PON1) activity and lipid hydroperoxide (LOOH) levels in both groups were measured. Results The low-density lipoprotein cholesterol (LDL-C) and hs-CRP levels were higher in ACS group than in control group (P0.05). Conclusions The incapacitation of HDL subclasses may occur in ACS patients, with an attenuated antioxidant ability and accentuated proinflammatory function. Mature HDL2 possesses better anti-inflammatory and antioxidant function than HDL3, thus playing a better cardioprotective effect.