The correlation of the quantitative ultrasonography parameters with the liver cancer cell proliferation activity and intralesional angiogenesis

Objective: To study the correlation of the quantitative ultrasonography parameters with liver cancer cell proliferation activity and intralesional angiogenesis. Methods: A total of 46 patients with liver cancer who received surgical resection in Hancheng People’s Hospital between June 2014 and March 2017 as well as 28 patients who received partial hepatectomy for abdominal trauma during the same period were selected, the patients with liver cancer received ultrasonography, and the quantitative parameters were calculated; the liver cancer tissue and adjacent tissue of patients with liver cancer as well as the normal liver tissue of patients with abdominal trauma were collected to determine the expression of proliferation genes, tumor suppressor genes and angiogenesis genes. Results: The IMAX of liver cancer tissue was significantly higher than that of adjacent tissue while the TTP, WT and mTT were significantly shorter than those of adjacent tissue; RNF180, Merlin, PICK1 and PTEN protein expression in liver cancer tissue and adjacent tissue were significantly lower than those in normal liver tissue, negatively correlated with the IMAX of liver cancer tissue, and positively correlated with the TTP, WT and mTT of liver cancer tissue; EphB4, SALL4, Cripto-1, VEGF, PDGF, EGFR and Ang-2 protein expression in liver cancer tissue and adjacent tissue were significantly higher than those in normal liver tissue, positively correlated with the IMAX of liver cancer tissue, and negatively correlated with the TTP, WT and mTT of liver cancer tissue. Conclusion: The changes in the quantitative parameters of liver cancer ultrasonography are valuable for evaluating the cell proliferation and angiogenesis.