Effects of tripterygium wilfordii combined with Salvia Miltiorrhiza therapy on renal function, coagulation function and immune response in children with purpura nephritis

Objective: To investigate the effects of tripterygium wilfordii combined with Salvia Miltiorrhiza therapy on renal function, coagulation function and immune response in children with purpura nephritis. Methods: A total of 70 children with purpura nephritis who were treated in the hospital between October 2013 and March 2017 were divided into control group (n=35) and Salvia Miltiorrhiza group (n=35) by random number table. Control group received routine + tripterygium wilfordii therapy, Salvia Miltiorrhiza group received routine + tripterygium wilfordii + Salvia Miltiorrhiza therapy, and the therapies lasted for 3 courses. The differences in renal function, coagulation function and immune response were compared between the two groups before and after treatment. Results: Before treatment, there was no statistically significant difference in renal function, coagulation function and immune response function between the two groups. After 3 courses of treatment, renal function indexes CysC, β 2 MG and 24 h UmAlb levels in Salvia Miltiorrhiza group were lower than those in control group; coagulation function indexes FIB and D-D levels in peripheral blood were lower than those of control group; immune response indexes Th1 cytokines IL-2 and IFN-γ contents in peripheral blood were higher than those of control group whereas Th2 cytokines IL-5 and IL-10 contents were lower than those of control group. Conclusion: Tripterygium wilfordii combined with Salvia Miltiorrhiza therapy can effectively optimize the renal function, reduce the hypercoagulation state and reduce the Th1/Th2 immune imbalance in children with purpura nephritis.