Effects of recombinant human growth hormone on the expression of CD47, L-selectin and advanced oxidation protein products in elderly patients with multiple organ dysfunction syndrome

Objective To investigate the effects of recombinant human growth hormone (rhGH) on the expression of CD47, L-selective action hormone (L-selectin), and advanced oxidation protein products (AOPPs) in elderly patients with multiple organ dysfunction syndrome (MODSE). Methods Sixty-six MODSE patients were randomly and equally divided into two groups (33 each): control group (received conventional treatment only) and rhGH treatment group (received conventional and rhGH treatment). Venous blood was taken from all the subjects before treatment and 3rd, 14th and 28th day after treatment. Serum CD47 was detected by flow cytometry, L-selectin and AOPPs concentrations were determined with ELISA and spectrophotometry. The changes in APACHE Ⅲ score in the two groups were also observed. Results Compared with that before treatment, the positive rate of CD47 was increased, meanwhile the AOPPs concentrations, L-selectin levels and APACHE Ⅲ scores declined markedly in both groups after treatment (P