ORGAN-SPECIFIC BIOMARKERS OF HUMAN AGING: THE CASE OF LIVER

Authors :: Capri, Miriam
Olivieri, F.
Remondini, Daniel
Lanzarini, Catia
Lazzarini, R.
Bellavista, Elena
Martucci, Morena
Santoro, Aurelia
Biondi, Fiammetta
Tenedini, E.
Tagliafico, E.
Vasuri, Francesco
D'Errico, Antonietta
Dazzi, Alessandro
Pellegrini, Sara
Castellani, Gastone
Procopio, A.
Cescon, Matteo
Grazi, GIAN LUCA
Franceschi, Claudio
EDITED BY GASTONE CASTELLANI, CLAUDIO FRANCESCHI, LUCIANO MILANESI AND DANIEL REMONDINI
M. Capri
F. Olivieri
D. Remondini
C. Lanzarini
R. Lazzarini
E. Bellavista
M. Martucci
A. Santoro
F. Biondi
E. Tenedini
E. Tagliafico
F. Vasuri
A. D’Errico
A. Dazzi
S. Pellegrini
G. Castellani
A. Procopio
M. Cescon
GL. Grazi
C. Franceschi
Publication Year :: 2011
Publisher :: Bononia University Press, 2011.
Abstract: We faced the basic question on chronological versus biological age at tissue level in the context of organ transplant. By means of a comprehensive approach we analysed nuclear and mitochondrial DNA, mRNAs, microRNAs, proteins, including proteasome and immunoproteasome, obtained from liver biopsies of donors with different age (13-90 years) to identify biomarkers of biological age. Telomere length and specific miRNAs appear to be important biomarkers of liver aging. This research looks for the improvement of the graft management getting insights into donor- recipient age- mismatch effects.

Subjects :: gene expression transcripts
Liver ageing
microRNA
Liver ageing, microRNAs, Liver transplant, gene expression transcripts
Liver transplant
NO
microRNAs

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