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A novel Alzheimer disease locus located near the gene encoding tau protein
- Source :
- Molecular psychiatry, vol 21, iss 1
- Publication Year :
- 2016
- Publisher :
- eScholarship, University of California, 2016.
-
Abstract
- APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer's Project (IGAP) Consortium in APOE ɛ4+ (10 352 cases and 9207 controls) and APOE ɛ4- (7184 cases and 26 968 controls) subgroups as well as in the total sample testing for interaction between a single-nucleotide polymorphism (SNP) and APOE ɛ4 status. Suggestive associations (P
- Subjects :
- Aging
Apolipoprotein E4
tau Proteins
Neurodegenerative
Alzheimer's Disease
Medical and Health Sciences
Chromosomes
Alzheimer Disease
IGAP Consortium
Genetics
Acquired Cognitive Impairment
Humans
2.1 Biological and endogenous factors
Polymorphism
Aetiology
Psychiatry
Pair 17
Prevention
Human Genome
Psychology and Cognitive Sciences
Neurosciences
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
Single Nucleotide
Biological Sciences
Brain Disorders
Neurological
Dementia
Human
Genome-Wide Association Study
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Molecular psychiatry, vol 21, iss 1
- Accession number :
- edsair.dedup.wf.001..cd47ff3240562f48271fd490e5ef55df