Increased bone turnover markers after renal transplantation

Bone remodeling is a process that occurs continuously in a seemingly inactive tissue like bone. Because of decreased votamin D synthesis, phosphorus retention and decreased calcium blood concentration, patients with chronic renal failure develop secondary hyperparathyroidism. Elevated PTH levels shifts balance between osteoblast and osteoclast activity in favor of osteoblast activity and therefore bone resorption. We presumed that renal transplantation reverses bone metabolism disorder and our goal was to establishe whether osteoblast and osteoclast activity returns to the levels of healthy individuals.