Kardiale Mehrschicht Computertomographie : Eignung von 'Niedrig-Kontrast-Datensätzen' zur linksventrikulären Volumetrie bei Patienten mit hypertropher Kardiomyopathie variabler Ausprägung

Introduction: Late enhanced multi-slice computed tomography (leMDCT) introduced for the visualization of late enhancement (LE) indicating intramyocardial fibrosis in Hypertrophic Cardiomyopathy (HCM) leaves the left-ventricular (LV) cavity with low contrast at the time of scanning. With regard to potentential risk stratification we analysed whether leMDCT-datasets additionally allow for volumetric LV assessment. Methods: We prospectively included HCM-patients to perform leMDCT (64 slice-CT) followed by the gold standard, cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) (1.5T). Dye was injected 7 minutes (Iopromid; 150mL) in leMDCT and 12 minutes (Gadolinium; 15mL 0.15mmoL/kgBW) in LGE-CMR before scanning. After creating three groups (0=no, 1=borderline and 2=sufficient LV-contrast) all reconstructed short cardiac axis views were manually and semiautomatically assessed and correlated with regard to LV muscle mass (MM) and other prognostically relevant volumetric parameters. Results: Mean age was 64.2±14 years of age. The three groups of varying contrast differed in weight and body mass index (p