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Monoklonal gammopati med ubestemt signifikans

Authors :
Hermansen, Niels Emil Ulrich
Silkjaer, Trine
Toftmann Hansen, Charlotte
Aagaard, Thomas Granum
Gregersen, Henrik
Source :
Hermansen, N E U, Silkjær, T, Hansen, C T, Aagaard, T G & Gregersen, H 2020, ' Monoklonal gammopati med ubestemt signifikans ', Ugeskrift for Laeger, bind 182, nr. 20, V08190428, s. 1861-1865 . < https://ugeskriftet.dk/videnskab/monoklonal-gammopati-med-ubestemt-signifikans >, Hermansen, N E U, Silkjaer, T, Toftmann Hansen, C, Aagaard, T G & Gregersen, H 2020, ' Monoklonal gammopati med ubestemt signifikans ', Ugeskrift for Laeger, bind 182, nr. 20, V08190428 . < https://ugeskriftet.dk/videnskab/monoklonal-gammopati-med-ubestemt-signifikans >
Publication Year :
2020

Abstract

This review summarises the work-up of patients with monoclonal gammopathy of undetermined significance (MGUS). In persons above 70 years of age, around 5% have MGUS, a premalignant state with a monoclonal plasma immunoglobulin or light chain (M protein) in blood and/or urine. Continuous follow-up is recommended due to a risk of malignant progression of around 1% per year. Immunoglobulin M MGUS primarily progresses to Waldenstr&#246;m&#39;s macroglobulinaemia, whereas non-immunoglobulin M MGUS typically progresses to multiple myeloma or amyloid light-chain amyloidosis. Treatment is unnecessary unless in rare cases of severe non-malignant complications. Screening is not advised.

Details

Language :
Danish
Database :
OpenAIRE
Journal :
Hermansen, N E U, Silkj&#230;r, T, Hansen, C T, Aagaard, T G &amp; Gregersen, H 2020, &#39; Monoklonal gammopati med ubestemt signifikans &#39;, Ugeskrift for Laeger, bind 182, nr. 20, V08190428, s. 1861-1865 . < https://ugeskriftet.dk/videnskab/monoklonal-gammopati-med-ubestemt-signifikans >, Hermansen, N E U, Silkjaer, T, Toftmann Hansen, C, Aagaard, T G &amp; Gregersen, H 2020, &#39; Monoklonal gammopati med ubestemt signifikans &#39;, Ugeskrift for Laeger, bind 182, nr. 20, V08190428 . < https://ugeskriftet.dk/videnskab/monoklonal-gammopati-med-ubestemt-signifikans >
Accession number :
edsair.dedup.wf.001..b28bc40b549160221b856826cd904426