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[Kidney and HIV infection]
- Source :
- La Presse medicale, La Presse medicale, Paris, Masson et Cie, 2012, 41 (3 Pt 1), pp.267-75. ⟨10.1016/j.lpm.2011.11.011⟩, La Presse medicale, 2012, 41 (3 Pt 1), pp.267-75. ⟨10.1016/j.lpm.2011.11.011⟩
- Publication Year :
- 2012
- Publisher :
- HAL CCSD, 2012.
-
Abstract
- International audience; Screening of chronic kidney disease (CKD) that includes estimation of the glomerular filtration rate (GFR) and evaluation proteinuria should be performed in all HIV-infected patients and these parameters have to be monitored annually in patients at higher risk for CKD. Black patients have a genetic predisposition to develop HIV-associated nephropathy. Suppression of HIV viral replication with antiretroviral therapy prevents the development of HIV-associated nephropathy or halts its progression. Kidney biopsy remains the most informative diagnosis test to differentiate various forms of kidney diseases in HIV-infected patients. Dosing antiretroviral agents with kidney metabolism should be adjusted when eGFR is bellow 50 mL/min/1.73 m(2). eGFR and serum phosphorus at baseline and during treatment should be carefully assessed in patients receiving tenofovir. Proximal renal tubular toxicity must be further evaluated in the presence of eGFR decrease and/or hypophosphatemia under tenofovir therapy.
- Subjects :
- MESH: Kidney Diseases
MESH: Adenine
MESH: Humans
urogenital system
MESH: Virus Replication
MESH: Genetic Predisposition to Disease
virus diseases
MESH: Kidney
MESH: Receptor, Epidermal Growth Factor
urologic and male genital diseases
female genital diseases and pregnancy complications
MESH: Male
MESH: HIV-1
MESH: Biopsy
MESH: Glomerular Filtration Rate
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
MESH: African Continental Ancestry Group
MESH: Anti-HIV Agents
MESH: Phosphorus
MESH: AIDS-Associated Nephropathy
MESH: Organophosphonates
MESH: Female
Subjects
Details
- Language :
- French
- ISSN :
- 00327867
- Database :
- OpenAIRE
- Journal :
- La Presse medicale, La Presse medicale, Paris, Masson et Cie, 2012, 41 (3 Pt 1), pp.267-75. ⟨10.1016/j.lpm.2011.11.011⟩, La Presse medicale, 2012, 41 (3 Pt 1), pp.267-75. ⟨10.1016/j.lpm.2011.11.011⟩
- Accession number :
- edsair.dedup.wf.001..a8ada9cb71dc1704de3251c82555d047