Highly Regio-Selective Organocatalytic formation of Carbamates from Substituted Cyclic Carbonates

A highly regio-selective catalytic approach has been developed towards carbamates derived from cyclic organic carbonates by reaction of the latter with amine reagents under organo-catalytic control. For various combinations of carbonate and amine substrates, an organocatalyst (TBD: triazabicyclodecene) was used to increase the reaction kinetics while exerting excellent regio- selective control. The current method is the first general approach towards the control over the regio-selectivity of this reaction using a wide variety of easily accessed substituted organic carbonates.