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99mTc tetrofosmin cardiac tomography after nitrate administration in patients with coronary artery disease and left vetricular dysfunction | Tomografia cardiaca con 99mTc tetrofosmina dopo somministrazione di nitrati in pazienti con cardiopatia ischemica e disfunzione ventricolare sinistra

Authors :
Menna, F.
Acampa, W.
Florimonte, L.
Ferro, A.
Borrelli, G.
Mainolfi, C.
Alberto Cuocolo
Source :
Scopus-Elsevier, La Radiologia medica (Testo stamp.) 99 (2000): 258–263., info:cnr-pdr/source/autori:Menna, Francesco; Acampa, Wanda; Florimonte, Luigia; Ferro, Adele; Borrelli, Giovanni; Mainolfi, Ciro; Cuocolo, A./titolo:99mTc tetrofosmin cardiac tomography after nitrate administration in patients with coronary artery disease and left vetricular dysfunction | Tomografia cardiaca con 99mTc tetrofosmina dopo somministrazione di nitrati in pazienti con cardiopatia ischemica e disfunzione ventricolare sinistra/doi:/rivista:La Radiologia medica (Testo stamp.)/anno:2000/pagina_da:258/pagina_a:263/intervallo_pagine:258–263/volume:99

Abstract

Purpose. To investigate the role of technetium-99m (99mTc) tetrofosmin single-photon emission Computed Tomography (SPECT) associated with nitrate administration in the detection of hypoperfused but still viable myocardium in patients with chronic coronary artery disease and left ventricular (LV) dysfunction. Material and methods. Twenty-two patients (mean age 54±11 years) with coronary artery disease, previous myocardial infarction and LV dysfunction (LV ejection fraction 38±13%) were examined. On differente days all patients underwent 99mTc tetrofosmin (740 MBq) SPECT under control conditions at rest and after sublingual nitroglycerin administration (10 mg). Regional tetrofosmin activity was quantitatively measured in 22 myocardial segments per patient. In each segment, tracer uptake was expressed as a percentage of the region with the peak activity. Results. Under control conditions, 267 myocardial segments (55%) showed normal tetrofosmin uptake (>70% of peak activity), 107 segments (22%) showed a moderate reduction (51- 70%) and 110 segments (23%) a severe reduction (=10% of after nitrate administration (from 44±5% to 58±3%, p

Details

Database :
OpenAIRE
Journal :
Scopus-Elsevier, La Radiologia medica (Testo stamp.) 99 (2000): 258–263., info:cnr-pdr/source/autori:Menna, Francesco; Acampa, Wanda; Florimonte, Luigia; Ferro, Adele; Borrelli, Giovanni; Mainolfi, Ciro; Cuocolo, A./titolo:99mTc tetrofosmin cardiac tomography after nitrate administration in patients with coronary artery disease and left vetricular dysfunction | Tomografia cardiaca con 99mTc tetrofosmina dopo somministrazione di nitrati in pazienti con cardiopatia ischemica e disfunzione ventricolare sinistra/doi:/rivista:La Radiologia medica (Testo stamp.)/anno:2000/pagina_da:258/pagina_a:263/intervallo_pagine:258–263/volume:99
Accession number :
edsair.dedup.wf.001..9ade8f94dd9015df39c1a964388104d7